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Showing 1 to 12 of 389 entries
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Circulating micrornas associated with glycemic impairment and progression in Asian Indians.

Biomarker research

Flowers E, Gadgil M, Aouizerat BE, Kanaya AM.
PMID: 26966540
Biomark Res. 2015 Oct 13;3:22. doi: 10.1186/s40364-015-0047-y. eCollection 2015.

AIMS/HYPOTHESIS: Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeostasis and have not been previously studied in...

Evaluation of Caspase-9b and PP2Acα2 as potential biomarkers for chronic lymphocytic leukemia.

Biomarker research

Domínguez-Berrocal L, Zhang X, Zini JM, Fominaya J, Rebollo A, Bravo J.
PMID: 27152197
Biomark Res. 2016 May 04;4:9. doi: 10.1186/s40364-016-0063-6. eCollection 2016.

BACKGROUND: Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα are functionally related in a direct interaction, which constitutes a promising target...

Paediatric acute myeloid leukaemia with the t(7;12)(q36;p13) rearrangement: a review of the biological and clinical management aspects.

Biomarker research

Tosi S, Mostafa Kamel Y, Owoka T, Federico C, Truong TH, Saccone S.
PMID: 26605042
Biomark Res. 2015 Oct 05;3:21. doi: 10.1186/s40364-015-0041-4. eCollection 2015.

The presence of chromosomal abnormalities is one of the most important criteria for leukaemia diagnosis and management. Infant leukaemia is a rare disease that affects children in their first year of life. It has been estimated that approximately one...

CEPP regimen (cyclophosphamide, etoposide, procarbazine and prednisone) as initial treatment for Hodgkin lymphoma patients presenting with severe abnormal liver function.

Biomarker research

Thakar K, Novero A, Das A, Lisinschi A, Mehta B, Ahmed T, Liu D.
PMID: 24991411
Biomark Res. 2014 Jun 23;2:12. doi: 10.1186/2050-7771-2-12. eCollection 2014.

ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to initial therapy, especially in the presence of renal and liver failure. We hereby present...

Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model.

Biomarker research

Xu HN, Nioka S, Li LZ.
PMID: 24252270
Biomark Res. 2013 Jan 17;1(1):6. doi: 10.1186/2050-7771-1-6.

BACKGROUND: Metabolic alteration is one of the hallmarks of carcinogenesis. We aimed to identify certain metabolic biomarkers for the early detection of pancreatic cancer (PC) using the transgenic PTEN-null mouse model. Pancreas-specific deletion of PTEN in mouse caused progressive...

Integration of a bacterial gene sequence into a chronic eosinophilic leukemia patient's genome as part of a fusion gene linker.

Biomarker research

Sidhoo S, Rosales JL, Lee KY.
PMID: 28593047
Biomark Res. 2017 Jun 05;5:20. doi: 10.1186/s40364-017-0101-z. eCollection 2017.

Analysis of databases from the human genome project (HGP), the 1000 Genomes Project (1KGP), and The Cancer Genome Atlas (TCGA) revealed bacterial DNA integration into the human somatic genome, particularly in tumor tissues. Fusion genes have also been associated...

Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers.

Biomarker research

Calatayud D, Dehlendorff C, Boisen MK, Hasselby JP, Schultz NA, Werner J, Immervoll H, Molven A, Hansen CP, Johansen JS.
PMID: 28239461
Biomark Res. 2017 Feb 21;5:8. doi: 10.1186/s40364-017-0087-6. eCollection 2017.

BACKGROUND: The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.METHODS: Expression of 46 selected microRNAs was studied in formalin-fixed paraffin-embedded...

A panel of glycoproteins as candidate biomarkers for early diagnosis and treatment evaluation of B-cell acute lymphoblastic leukemia.

Biomarker research

Cavalcante Mde S, Torres-Romero JC, Lobo MD, Moreno FB, Bezerra LP, Lima DS, Matos JC, Moreira Rde A, Monteiro-Moreira AC.
PMID: 26823978
Biomark Res. 2016 Jan 27;4:1. doi: 10.1186/s40364-016-0055-6. eCollection 2016.

BACKGROUND: Acute lymphoblastic leukemia is the most common malignant cancer in childhood. The signs and symptoms of childhood cancer are difficult to recognize, as it is not the first diagnosis to be considered for nonspecific complaints, leading to potential...

Diagnostic and prognostic microRNAs in the serum of breast cancer patients measured by droplet digital PCR.

Biomarker research

Mangolini A, Ferracin M, Zanzi MV, Saccenti E, Ebnaof SO, Poma VV, Sanz JM, Passaro A, Pedriali M, Frassoldati A, Querzoli P, Sabbioni S, Carcoforo P, Hollingsworth A, Negrini M.
PMID: 26120471
Biomark Res. 2015 Jun 06;3:12. doi: 10.1186/s40364-015-0037-0. eCollection 2015.

BACKGROUND: Breast cancer circulating biomarkers include carcinoembryonic antigen and carbohydrate antigen 15-3, which are used for patient follow-up. Since sensitivity and specificity are low, novel and more useful biomarkers are needed. The presence of stable circulating microRNAs (miRNAs) in...

Nuclear protein IK undergoes dynamic subcellular translocation and forms unique nuclear bodies during the cell cycle.

Biomarker research

Hu L, Yang F, Liu X, Xu D, Dai W.
PMID: 24252166
Biomark Res. 2013 Feb 18;1(1):11. doi: 10.1186/2050-7771-1-11.

IK is a nuclear protein containing a unique domain named RED due to the presence of a repetitive arginine (R), aspartic (E), and glutamic acid (D) sequence. To date, the function of this protein remains largely unknown despite of...

The emerging roles of Notch signaling in leukemia and stem cells.

Biomarker research

Liu N, Zhang J, Ji C.
PMID: 24252593
Biomark Res. 2013 Jul 18;1(1):23. doi: 10.1186/2050-7771-1-23.

The Notch signaling pathway plays a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis, and is a highly conserved signaling pathway that regulates normal development in a context- and dose-dependent manner. Dysregulation of Notch signaling...

Metabolomic analyses for atherosclerosis, diabetes, and obesity.

Biomarker research

Du F, Virtue A, Wang H, Yang XF.
PMID: 24252331
Biomark Res. 2013 Apr 01;1(1):17. doi: 10.1186/2050-7771-1-17.

Insulin resistance associated with type 2 diabetes mellitus (T2DM), obesity, and atherosclerosis is a global health problem. A portfolio of abnormalities of metabolic and vascular homeostasis accompanies T2DM and obesity, which are believed to conspire to lead to accelerated...

Showing 1 to 12 of 389 entries